Oxidant Damage Induced by Exercise in Alaskan Sled Dogs

by Kenneth W. Hinchcliff, Gregory A. Reinhart, Robert DiSilvestro, Arleigh Reynolds, Richard Swenson and Ashley Blomstein Fujii

Exercise imposes an oxidative stress in many species. The oxidant stress is imposed because the use of oxygen in metabolism results in the production of reactive oxygen species, such as hydroxyl radicals. The greater oxygen consumption that occurs during exercise presumably increases the amount of these reactive oxygen species. The reactive oxygen species, so called free radicals, are absorbed by antioxidants such as vitamin E, glutahione and antioxidant enzymes. Recently, we examined the effect of 3 consecutive days of exercise on an index of oxidant stress, the plasma isoprostane concentration, and on serum vitamin E and other antioxidant substances. Exercise was associated with a significant decline in serum vitamin E concentration, an increase in plasma isoprostane concentration, and an increase in serum creatine kinase activity. Whether the reduction in serum vitamin E concentration was causally associated with the change in serum CK activity is unknown. However, these results do suggest that exercise is associated with oxidative stress in dogs, and that repetitive exercise may result in consumption of body antioxidant reserves.

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